| 1. Round | 24/07/2021 | Deportivo Guadalajara [U18] | - | Atlético San Luis [U18] | 6:0 | ||||
| 2. Round | 30/07/2021 | Puebla FC [U18] | - | Deportivo Guadalajara [U18] | 1:3 | ||||
| 3. Round | 07/08/2021 | Deportivo Guadalajara [U18] | - | FC Juárez [U18] | 1:2 |  |
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| 4. Round | 15/08/2021 | Santos Laguna [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 5. Round | 18/08/2021 | Deportivo Guadalajara [U18] | - | Club León [U18] | 1:1 | ||||
| 9. Round | 18/09/2021 | Deportivo Guadalajara [U18] | - | CF Pachuca [U18] | 0:4 | |
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| 10. Round | 25/09/2021 | CF América [U18] | - | Deportivo Guadalajara [U18] | 5:1 | ||||
| 11. Round | 29/09/2021 | Gallos Blancos [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 12. Round | 02/10/2021 | Deportivo Guadalajara [U18] | - | Atlas Guadalajara [U18] | 3:0 | ||||
| 13. Round | 17/10/2021 | Deportivo Guadalajara [U18] | - | Deportivo Toluca [U18] | 2:2 | ||||
| 17. Round | 05/11/2021 | Mazatlán FC [U18] | - | Deportivo Guadalajara [U18] | 2:1 | |
Mexico