| 5. Round | 23/08/2021 | PFC Beroe | - | Botev Vratsa | 1:0 | ||||
| 6. Round | 28/08/2021 | Botev Vratsa | - | Lokomotiv Plovdiv | 0:0 | ||||
| 7. Round | 12/09/2021 | CSKA 1948 Sofia | - | Botev Vratsa | 5:1 | ||||
| 8. Round | 19/09/2021 | Botev Vratsa | - | CSKA Sofia | 2:4 | ||||
| 9. Round | 26/09/2021 | PFC Ludogorets Razgrad | - | Botev Vratsa | 3:1 |  |
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| 10. Round | 02/10/2021 | Botev Vratsa | - | Lokomotiv Sofia | 2:2 | ||||
| 11. Round | 15/10/2021 | Pirin Blagoevgrad | - | Botev Vratsa | 3:1 | ||||
| 12. Round | 23/10/2021 | Botev Vratsa | - | Cherno More Varna | 0:0 | ||||
| 14. Round | 07/11/2021 | Arda Kardzhali | - | Botev Vratsa | 3:2 |  |
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| 15. Round | 22/11/2021 | Levski Sofia | - | Botev Vratsa | 0:0 | |
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| 16. Round | 26/11/2021 | Botev Vratsa | - | Tsarsko Selo Sofia | 0:0 | |
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