| 1. Round | 19/10/2020 | Cerro Porteño | - | Sportivo Luqueño | 2:0 | ||||
| 2. Round | 26/10/2020 | Guaraní | - | Cerro Porteño | 1:1 |  |
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| 3. Round | 31/10/2020 | Cerro Porteño | - | Libertad | 1:0 | ||||
| 4. Round | 07/11/2020 | Guaireña FC | - | Cerro Porteño | 1:1 | ||||
| 7. Round | 20/11/2020 | River Plate | - | Cerro Porteño | 1:2 | ||||
| 5. Round | 26/11/2020 | Cerro Porteño | - | Sol de América | 0:0 | |
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| 8. Round | 29/11/2020 | Cerro Porteño | - | General Díaz | 3:1 | |
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| 6. Round | 03/12/2020 | Cerro Porteño | - | Club Olimpia | 1:0 | ||||
| 9. Round | 07/12/2020 | Club Nacional | - | Cerro Porteño | 4:3 | ||||
| 10. Round | 13/12/2020 | Cerro Porteño | - | San Lorenzo | 1:1 | |
Paraguay