| 2. Round | 01/08/2021 | FC Vaduz | - | Neuchâtel Xamax FCS | 1:2 | ||||
| 3. Round | 06/08/2021 | Neuchâtel Xamax FCS | - | SC Kriens | 4:0 | ||||
| 1. Round | 10/08/2021 | Neuchâtel Xamax FCS | - | FC Aarau | 4:2 | ||||
| 4. Round | 21/08/2021 | Yverdon Sport FC | - | Neuchâtel Xamax FCS | 1:1 | ||||
| 9. Round | 01/10/2021 | FC Schaffhausen | - | Neuchâtel Xamax FCS | 4:0 | ||||
| 10. Round | 15/10/2021 | Neuchâtel Xamax FCS | - | FC Vaduz | 0:2 | ||||
| 11. Round | 22/10/2021 | FC Wil 1900 | - | Neuchâtel Xamax FCS | 2:1 | ||||
| 12. Round | 29/10/2021 | Neuchâtel Xamax FCS | - | FC Winterthur | 1:1 |  |
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| 14. Round | 20/11/2021 | SC Kriens | - | Neuchâtel Xamax FCS | 0:1 | ||||
| 18. Round | 17/12/2021 | FC Aarau | - | Neuchâtel Xamax FCS | 1:0 | ||||
| 23. Round | 25/02/2022 | Neuchâtel Xamax FCS | - | SC Kriens | 2:1 | ||||
| 24. Round | 01/03/2022 | FC Thun | - | Neuchâtel Xamax FCS | 1:2 | ||||
| 25. Round | 04/03/2022 | Neuchâtel Xamax FCS | - | FC Vaduz | 2:4 | ||||
| 26. Round | 12/03/2022 | FC Wil 1900 | - | Neuchâtel Xamax FCS | 2:0 | ||||
| 36. Round | 21/05/2022 | Neuchâtel Xamax FCS | - | FC Wil 1900 | 5:2 |
France
Portugal