2. Round | 10/06/2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
3. Round | 16/06/2021 | Albion | - | Defensor Sporting | 2:2 | ||||
4. Round | 26/06/2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
5. Round | 01/07/2021 | Atenas | - | Defensor Sporting | 2:0 | ||||
6. Round | 09/07/2021 | Defensor Sporting | - | Racing | 1:4 | ||||
8. Round | 22/07/2021 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 | ||||
9. Round | 28/07/2021 | Uruguay Montevideo | - | Defensor Sporting | 0:2 | ||||
16. Round | 12/10/2021 | Defensor Sporting | - | Atenas | 1:1 | ||||
17. Round | 20/10/2021 | Racing | - | Defensor Sporting | 0:1 | ||||
19. Round | 02/11/2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 | ||||
20. Round | 10/11/2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 | ||||
21. Round | 18/11/2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | ||||
22. Round | 24/11/2021 | Defensor Sporting | - | Danubio | 0:1 |