| 1. Round | 18/07/2021 | River Plate | - | Colón de Santa Fe | 1:2 |  |
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| 2. Round | 25/07/2021 | River Plate | - | Unión de Santa Fe | 4:0 | |
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| 3. Round | 29/07/2021 | Lanús | - | River Plate | 0:3 | ||||
| 6. Round | 14/08/2021 | River Plate | - | Vélez Sarsfield | 2:0 | ||||
| 7. Round | 23/08/2021 | Gimnasia de La Plata | - | River Plate | 1:1 | |
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| 8. Round | 27/08/2021 | River Plate | - | Aldosivi | 2:0 | ||||
| 12. Round | 20/09/2021 | River Plate | - | Arsenal de Sarandí | 1:0 | ||||
| 14. Round | 03/10/2021 | River Plate | - | Boca Juniors | 2:1 |
Argentina
Belgium