| 11. Round | 01/08/2022 | River Plate | - | Sarmiento de Junín | 1:2 | ||||
| 12. Round | 07/08/2022 | Independiente | - | River Plate | 0:1 |  |
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| 13. Round | 14/08/2022 | River Plate | - | Newell's Old Boys | 4:1 | |
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| 16. Round | 28/08/2022 | Tigre | - | River Plate | 1:1 | ||||
| 17. Round | 05/09/2022 | River Plate | - | Barracas Central | 2:0 | ||||
| 18. Round | 11/09/2022 | Boca Juniors | - | River Plate | 1:0 | ||||
| 19. Round | 14/09/2022 | River Plate | - | Banfield | 1:2 | ||||
| 20. Round | 18/09/2022 | San Lorenzo | - | River Plate | 0:1 |  |
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| 23. Round | 06/10/2022 | River Plate | - | Estudiantes | 5:0 | |
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| 24. Round | 10/10/2022 | Patronato de Paraná | - | River Plate | 0:1 | ||||
| 25. Round | 13/10/2022 | River Plate | - | Platense | 2:1 | |
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| 26. Round | 17/10/2022 | River Plate | - | Rosario Central | 1:2 | |
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| 27. Round | 23/10/2022 | Racing Club | - | River Plate | 1:2 |
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