19. Round | 29/08/2021 | Ñublense | - | Melipilla | 3:0 | ||||
20. Round | 07/09/2021 | Melipilla | - | Unión Española | 0:3 | ||||
21. Round | 15/09/2021 | Palestino | - | Melipilla | 3:1 | ||||
24. Round | 04/10/2021 | Melipilla | - | Santiago Wanderers | 1:1 | ||||
25. Round | 09/10/2021 | Antofagasta | - | Melipilla | 1:0 | ||||
31. Round | 10/11/2021 | Colo-Colo | - | Melipilla | 1:0 | ||||
34. Round | 05/12/2021 | Huachipato | - | Melipilla | 3:1 |