| 2. Round | 27/09/2021 | Saltillo FC | - | Alacranes de Durango | 1:1 | ||||
| 3. Round | 02/10/2021 | Cimarrones de Sonora II | - | Saltillo FC | 2:2 | ||||
| 4. Round | 09/10/2021 | Saltillo FC | - | Correcaminos UAT II | 1:0 |  |
|||
| 6. Round | 16/10/2021 | Catedráticos Elite | - | Saltillo FC | 1:0 | ||||
| 10. Round | 11/11/2021 | Colima FC | - | Saltillo FC | 1:2 | ||||
| 11. Round | 13/11/2021 | Saltillo FC | - | Leones Negros II | 3:1 | |
|||
| 13. Round | 27/11/2021 | Saltillo FC | - | Mineros de Fresnillo FC | 4:2 |
Mexico