| 1. Round | 10/07/2016 | Sportivo Luqueño | - | Club Olimpia | 0:1 | ||||
| 2. Round | 16/07/2016 | Club Rubio Ñu | - | Club Olimpia | 0:0 | ||||
| 3. Round | 21/07/2016 | Club Olimpia | - | General Caballero ZC | 0:0 | ||||
| 4. Round | 24/07/2016 | River Plate | - | Club Olimpia | 0:2 | ||||
| 6. Round | 06/08/2016 | Cerro Porteño | - | Club Olimpia | 1:1 | ||||
| 7. Round | 14/08/2016 | Club Olimpia | - | Sol de América | 1:0 | ||||
| 8. Round | 20/08/2016 | Club Nacional | - | Club Olimpia | 3:4 | ||||
| 9. Round | 28/08/2016 | Club Olimpia | - | Libertad | 1:1 | ||||
| 10. Round | 11/09/2016 | General Díaz | - | Club Olimpia | 1:2 |  |
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| 11. Round | 18/09/2016 | Club Olimpia | - | Guaraní | 0:1 |  |
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| 12. Round | 25/09/2016 | Club Olimpia | - | Sportivo Luqueño | 4:1 | ||||
| 13. Round | 02/10/2016 | Club Olimpia | - | Club Rubio Ñu | 3:1 | ||||
| 19. Round | 26/11/2016 | Club Olimpia | - | Club Nacional | 2:1 | ||||
| 20. Round | 04/12/2016 | Libertad | - | Club Olimpia | 2:2 | ||||
| 22. Round | 18/12/2016 | Guaraní | - | Club Olimpia | 0:1 |
Paraguay