| 7. Round | 05/08/2022 | Club León [] | - | Atlético San Luis [] | 2:0 | ||||
| 10. Round | 27/08/2022 | Club León [] | - | Atlas Guadalajara [] | 5:0 | ||||
| 13. Round | 18/09/2022 | Atlético San Luis [] | - | Club León [] | 0:4 | ||||
| 14. Round | 24/09/2022 | Club León [] | - | CF Monterrey [] | 2:2 | ||||
| 16. Round | 08/10/2022 | Club León [] | - | Deportivo Guadalajara [] | 1:1 | ||||
| 15. Round | 12/10/2022 | Club Tijuana [] | - | Club León [] | 5:1 | ||||
| 18. Round | 22/10/2022 | UANL Tigres [] | - | Club León [] | 3:1 |
Mexico