| 1. Round | 10/01/2021 | Deportivo Toluca [U20] | - | Gallos Blancos [U20] | 1:2 | ||||
| 2. Round | 17/01/2021 | Gallos Blancos [U20] | - | Atlas Guadalajara [U20] | 3:0 |  |
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| 3. Round | 24/01/2021 | Gallos Blancos [U20] | - | Pumas UNAM [U20] | 1:3 | ||||
| 4. Round | 30/01/2021 | Cruz Azul [U20] | - | Gallos Blancos [U20] | 0:0 | ||||
| 5. Round | 04/02/2021 | Gallos Blancos [U20] | - | CF Pachuca [U20] | 1:2 | ||||
| 6. Round | 13/02/2021 | CF América [U20] | - | Gallos Blancos [U20] | 4:0 | ||||
| 7. Round | 21/02/2021 | Gallos Blancos [U20] | - | Puebla FC [U20] | 0:1 | ||||
| 8. Round | 26/02/2021 | Mazatlán FC [U20] | - | Gallos Blancos [U20] | 3:1 | ||||
| 9. Round | 03/03/2021 | Gallos Blancos [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 10. Round | 06/03/2021 | CF Monterrey [U20] | - | Gallos Blancos [U20] | 5:1 | ||||
| 12. Round | 20/03/2021 | Club Tijuana [U20] | - | Gallos Blancos [U20] | 1:0 | ||||
| 13. Round | 04/04/2021 | Gallos Blancos [U20] | - | UANL Tigres [U20] | 1:4 | |
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| 14. Round | 11/04/2021 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 1:0 | |
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| 15. Round | 16/04/2021 | Club Necaxa [U20] | - | Gallos Blancos [U20] | 4:1 | ||||
| 16. Round | 25/04/2021 | Gallos Blancos [U20] | - | FC Juárez [U20] | 0:2 |
Mexico