| 4. Round | 10/02/2022 | FC Juárez | - | Deportivo Guadalajara | 1:3 | ||||
| 6. Round | 19/02/2022 | FC Juárez | - | Santos Laguna | 0:0 | ||||
| 7. Round | 26/02/2022 | FC Juárez | - | UANL Tigres | 2:3 | ||||
| 8. Round | 02/03/2022 | Puebla FC | - | FC Juárez | 1:1 | ||||
| 9. Round | 05/03/2022 | FC Juárez | - | Club León | 0:1 | ||||
| 10. Round | 12/03/2022 | FC Juárez | - | Atlas Guadalajara | 1:2 | ||||
| 5. Round | 16/03/2022 | CF Monterrey | - | FC Juárez | 3:0 | ||||
| 11. Round | 21/03/2022 | Club Tijuana | - | FC Juárez | 1:0 | ||||
| 12. Round | 03/04/2022 | FC Juárez | - | Pumas UNAM | 0:1 | ||||
| 13. Round | 10/04/2022 | CF América | - | FC Juárez | 3:0 | ||||
| 14. Round | 16/04/2022 | FC Juárez | - | CF Pachuca | 1:2 | ||||
| 15. Round | 20/04/2022 | Deportivo Toluca | - | FC Juárez | 0:1 | ||||
| 16. Round | 23/04/2022 | FC Juárez | - | Mazatlán FC | 0:2 | ||||
| 17. Round | 30/04/2022 | Gallos Blancos | - | FC Juárez | 4:0 |  |
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Uruguay