| 6. Round | 15/08/2021 | Rosario Central | - | Independiente | 1:2 | ||||
| 8. Round | 25/08/2021 | Rosario Central | - | Arsenal de Sarandí | 4:0 |  |
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| 9. Round | 29/08/2021 | Central Córdoba SdE | - | Rosario Central | 2:4 | ||||
| 10. Round | 05/09/2021 | Rosario Central | - | Boca Juniors | 1:2 | ||||
| 12. Round | 20/09/2021 | Rosario Central | - | San Lorenzo | 1:0 | ||||
| 15. Round | 08/10/2021 | Estudiantes | - | Rosario Central | 2:2 | ||||
| 16. Round | 15/10/2021 | Rosario Central | - | Patronato de Paraná | 3:2 | ||||
| 18. Round | 24/10/2021 | Rosario Central | - | Racing Club | 2:1 | ||||
| 19. Round | 31/10/2021 | Unión de Santa Fe | - | Rosario Central | 3:1 | |
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| 20. Round | 05/11/2021 | Defensa y Justicia | - | Rosario Central | 3:0 | ||||
| 21. Round | 20/11/2021 | Rosario Central | - | Atlético Tucumán | 3:1 | ||||
| 22. Round | 25/11/2021 | Colón de Santa Fe | - | Rosario Central | 1:4 | ||||
| 23. Round | 28/11/2021 | Rosario Central | - | River Plate | 2:2 | |
Venezuela