| 1. Round | 10/01/2021 | Deportivo Toluca | - | Gallos Blancos | 3:1 |  |
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| 2. Round | 16/01/2021 | Deportivo Guadalajara | - | Deportivo Toluca | 1:1 | ||||
| 3. Round | 24/01/2021 | Deportivo Toluca | - | Club Necaxa | 2:0 | |
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| 4. Round | 31/01/2021 | Club Tijuana | - | Deportivo Toluca | 3:2 | ||||
| 5. Round | 07/02/2021 | Deportivo Toluca | - | Mazatlán FC | 4:1 | ||||
| 6. Round | 14/02/2021 | Deportivo Toluca | - | Pumas UNAM | 1:0 | ||||
| 7. Round | 21/02/2021 | Cruz Azul | - | Deportivo Toluca | 3:2 |  |
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| 8. Round | 27/02/2021 | Deportivo Toluca | - | Atlas Guadalajara | 0:0 | ||||
| 9. Round | 03/03/2021 | UANL Tigres | - | Deportivo Toluca | 0:1 | ||||
| 10. Round | 06/03/2021 | Atlético San Luis | - | Deportivo Toluca | 0:0 | ||||
| 11. Round | 14/03/2021 | Deportivo Toluca | - | CF Pachuca | 0:2 | ||||
| 12. Round | 21/03/2021 | Deportivo Toluca | - | Puebla FC | 4:4 | |
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| 13. Round | 05/04/2021 | Club León | - | Deportivo Toluca | 2:1 | |
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| 14. Round | 11/04/2021 | Deportivo Toluca | - | CF Monterrey | 1:2 | ||||
| 15. Round | 19/04/2021 | Santos Laguna | - | Deportivo Toluca | 3:1 | ||||
| 16. Round | 25/04/2021 | Deportivo Toluca | - | CF América | 3:1 | |
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| 17. Round | 01/05/2021 | FC Juárez | - | Deportivo Toluca | 1:0 |
Ecuador