| 1. Round | 18/07/2010 | Viktoria Plzeň | - | Sigma Olomouc | 2:2 | ||||
| 2. Round | 25/07/2010 | Sigma Olomouc | - | FK Baumit Jablonec | 4:1 |  |
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| 3. Round | 02/08/2010 | 1. FK Příbram | - | Sigma Olomouc | 0:0 | ||||
| 4. Round | 08/08/2010 | Sigma Olomouc | - | FK Ústí nad Labem | 3:0 | ||||
| 5. Round | 14/08/2010 | Baník Ostrava | - | Sigma Olomouc | 1:2 | |
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| 6. Round | 22/08/2010 | Sigma Olomouc | - | Zbrojovka Brno | 3:0 | |
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| 7. Round | 27/08/2010 | Slavia Praha | - | Sigma Olomouc | 1:1 | |
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| 8. Round | 13/09/2010 | Sigma Olomouc | - | FK Mladá Boleslav | 0:0 | ||||
| 9. Round | 18/09/2010 | Sigma Olomouc | - | Slovan Liberec | 4:0 | |
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| 10. Round | 27/09/2010 | FK Teplice | - | Sigma Olomouc | 1:0 | ||||
| 11. Round | 04/10/2010 | Sigma Olomouc | - | AC Sparta Praha | 0:1 | ||||
| 12. Round | 18/10/2010 | 1. FC Slovácko | - | Sigma Olomouc | 0:2 | |
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| 13. Round | 24/10/2010 | Sigma Olomouc | - | Bohemians 1905 | 3:1 | |
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| 14. Round | 31/10/2010 | FC Hradec Králové | - | Sigma Olomouc | 1:0 | ||||
| 15. Round | 07/11/2010 | Sigma Olomouc | - | Dynamo České Budějovice | 5:1 | |
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| 16. Round | 14/11/2010 | FK Baumit Jablonec | - | Sigma Olomouc | 3:2 | |
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| 17. Round | 21/11/2010 | Sigma Olomouc | - | 1. FK Příbram | 3:1 | |
Czech Republic