| 4. Round | 27/08/2005 | Excelsior Mouscron | - | KVC Westerlo | 1:0 | ||||
| 5. Round | 10/09/2005 | KVC Westerlo | - | FC Brussels | 3:0 | ||||
| 6. Round | 18/09/2005 | KSV Roeselare | - | KVC Westerlo | 0:2 | ||||
| 10. Round | 15/10/2005 | Club Brugge KV | - | KVC Westerlo | 2:1 | ||||
| 13. Round | 06/11/2005 | Standard Liège | - | KVC Westerlo | 1:0 | ||||
| 14. Round | 20/11/2005 | KVC Westerlo | - | RSC Anderlecht | 2:1 | ||||
| 16. Round | 03/12/2005 | KVC Westerlo | - | SV Zulte Waregem | 2:2 | ||||
| 17. Round | 10/12/2005 | RAA La Louviére | - | KVC Westerlo | 0:3 | ||||
| 15. Round | 14/12/2005 | KAA Gent | - | KVC Westerlo | 0:1 | ||||
| 18. Round | 17/12/2005 | Cercle Brugge | - | KVC Westerlo | 2:2 | ||||
| 21. Round | 04/02/2006 | KVC Westerlo | - | Excelsior Mouscron | 0:5 | ||||
| 25. Round | 04/03/2006 | KVC Westerlo | - | Sint-Truidense VV | 2:1 | ||||
| 26. Round | 11/03/2006 | KSK Beveren | - | KVC Westerlo | 4:1 | ||||
| 27. Round | 18/03/2006 | KVC Westerlo | - | Club Brugge KV | 0:0 | ||||
| 28. Round | 25/03/2006 | Sporting Lokeren | - | KVC Westerlo | 3:2 |  |
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| 32. Round | 23/04/2006 | KVC Westerlo | - | KAA Gent | 0:1 | ||||
| 33. Round | 30/04/2006 | SV Zulte Waregem | - | KVC Westerlo | 1:2 |  |
Czech Republic