| 1. Round | 31/07/2009 | sc Heerenveen | - | Roda JC Kerkrade | 0:0 | ||||
| 3. Round | 15/08/2009 | sc Heerenveen | - | Vitesse | 1:0 | ||||
| 4. Round | 23/08/2009 | sc Heerenveen | - | AZ Alkmaar | 0:2 | ||||
| 6. Round | 12/09/2009 | sc Heerenveen | - | FC Groningen | 0:1 | ||||
| 7. Round | 20/09/2009 | sc Heerenveen | - | FC Twente | 0:2 | ||||
| 8. Round | 27/09/2009 | Sparta Rotterdam | - | sc Heerenveen | 0:2 | ||||
| 9. Round | 04/10/2009 | sc Heerenveen | - | VVV-Venlo | 1:1 | ||||
| 10. Round | 17/10/2009 | PSV Eindhoven | - | sc Heerenveen | 1:0 |  |
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| 11. Round | 25/10/2009 | Willem II | - | sc Heerenveen | 4:1 | |
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| 12. Round | 31/10/2009 | sc Heerenveen | - | ADO Den Haag | 3:0 | ||||
| 13. Round | 08/11/2009 | FC Utrecht | - | sc Heerenveen | 2:3 | ||||
| 14. Round | 22/11/2009 | AFC Ajax | - | sc Heerenveen | 5:1 | ||||
| 18. Round | 20/01/2010 | FC Groningen | - | sc Heerenveen | 2:0 | ||||
| 19. Round | 23/01/2010 | sc Heerenveen | - | Willem II | 4:2 | |
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| 21. Round | 02/02/2010 | VVV-Venlo | - | sc Heerenveen | 3:1 | ||||
| 22. Round | 06/02/2010 | sc Heerenveen | - | FC Utrecht | 2:0 | ||||
| 32. Round | 14/04/2010 | sc Heerenveen | - | PSV Eindhoven | 2:2 | |
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| 33. Round | 18/04/2010 | sc Heerenveen | - | NAC Breda | 0:0 |
Czech Republic