| 7. Round | 22/02/2021 | CF Pachuca [U20] | - | Deportivo Guadalajara [U20] | 3:2 | ||||
| 8. Round | 28/02/2021 | Deportivo Guadalajara [U20] | - | Pumas UNAM [U20] | 1:2 | ||||
| 9. Round | 03/03/2021 | Gallos Blancos [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 10. Round | 06/03/2021 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 2:1 | ||||
| 11. Round | 14/03/2021 | Deportivo Guadalajara [U20] | - | CF América [U20] | 1:1 | ||||
| 12. Round | 20/03/2021 | CF Monterrey [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 1. Round | 27/03/2021 | Puebla FC [U20] | - | Deportivo Guadalajara [U20] | 2:4 |  |
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| 13. Round | 04/04/2021 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 5:2 | ||||
| 14. Round | 10/04/2021 | Cruz Azul [U20] | - | Deportivo Guadalajara [U20] | 0:1 | ||||
| 15. Round | 17/04/2021 | Deportivo Guadalajara [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 16. Round | 24/04/2021 | Atlas Guadalajara [U20] | - | Deportivo Guadalajara [U20] | 3:2 | ||||
| 17. Round | 01/05/2021 | Deportivo Guadalajara [U20] | - | UANL Tigres [U20] | 1:1 |
Mexico