| 1. Round | 30/01/2010 | Guaraní | - | Libertad | 1:0 |  |
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| 4. Round | 17/02/2010 | Guaraní | - | Tacuary | 5:2 | ||||
| 5. Round | 21/02/2010 | Sportivo Luqueño | - | Guaraní | 1:2 | ||||
| 6. Round | 27/02/2010 | Guaraní | - | 3 de Febrero | 1:1 |  |
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| 7. Round | 06/03/2010 | Club Nacional | - | Guaraní | 1:0 | |
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| 8. Round | 13/03/2010 | Guaraní | - | Sportivo Trinidense | 2:0 | ||||
| 9. Round | 17/03/2010 | Sport Colombia | - | Guaraní | 1:3 | ||||
| 10. Round | 21/03/2010 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 11. Round | 27/03/2010 | Club Olimpia | - | Guaraní | 0:0 | |
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| 15. Round | 18/04/2010 | Tacuary | - | Guaraní | 1:4 | |
Paraguay