| 2. Round | 29/07/2017 | Club Nacional | - | Club Olimpia | 1:1 | ||||
| 3. Round | 06/08/2017 | Sol de América | - | Club Nacional | 1:1 | ||||
| 4. Round | 12/08/2017 | Club Rubio Ñu | - | Club Nacional | 0:1 |  |
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| 5. Round | 19/08/2017 | Club Nacional | - | Sportivo Luqueño | 1:1 | |
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| 6. Round | 27/08/2017 | Guaraní | - | Club Nacional | 3:2 | ||||
| 9. Round | 16/09/2017 | Club Nacional | - | Sportivo Trinidense | 0:5 | ||||
| 10. Round | 25/09/2017 | Independiente CG | - | Club Nacional | 1:2 | |
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| 11. Round | 01/10/2017 | Club Nacional | - | Libertad | 2:1 | ||||
| 13. Round | 15/10/2017 | Club Olimpia | - | Club Nacional | 2:0 | |
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| 14. Round | 18/10/2017 | Club Nacional | - | Sol de América | 1:1 | ||||
| 15. Round | 22/10/2017 | Club Nacional | - | Club Rubio Ñu | 1:1 | |
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| 17. Round | 05/11/2017 | Club Nacional | - | Guaraní | 0:4 | |
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| 7. Round | 08/11/2017 | Club Nacional | - | Cerro Porteño | 1:2 | ||||
| 19. Round | 20/11/2017 | Club Nacional | - | General Díaz | 2:0 | ||||
| 20. Round | 26/11/2017 | Sportivo Trinidense | - | Club Nacional | 1:1 | |
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| 21. Round | 04/12/2017 | Club Nacional | - | Independiente CG | 5:0 | ||||
| 22. Round | 10/12/2017 | Libertad | - | Club Nacional | 0:2 |
Paraguay