| 1. Round | 10/02/2022 | Patronato de Paraná | - | Argentinos Juniors | 0:1 | ||||
| 2. Round | 15/02/2022 | Argentinos Juniors | - | Newell's Old Boys | 3:0 |  |
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| 3. Round | 23/02/2022 | Racing Club | - | Argentinos Juniors | 3:0 | |
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| 4. Round | 28/02/2022 | Argentinos Juniors | - | San Lorenzo | 1:1 | ||||
| 5. Round | 05/03/2022 | Gimnasia de La Plata | - | Argentinos Juniors | 2:2 | |
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| 7. Round | 22/03/2022 | Argentinos Juniors | - | Vélez Sarsfield | 1:0 | ||||
| 8. Round | 02/04/2022 | Banfield | - | Argentinos Juniors | 0:2 | ||||
| 9. Round | 10/04/2022 | River Plate | - | Argentinos Juniors | 4:2 |  |
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| 11. Round | 21/04/2022 | Atlético Tucumán | - | Argentinos Juniors | 2:4 | ||||
| 12. Round | 26/04/2022 | Argentinos Juniors | - | Sarmiento de Junín | 0:0 | ||||
| 13. Round | 03/05/2022 | Platense | - | Argentinos Juniors | 1:1 | |
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| 14. Round | 08/05/2022 | Argentinos Juniors | - | Unión de Santa Fe | 2:1 |  |
Argentina