| 2. Round | 16/01/2021 | Cruz Azul [U20] | - | Puebla FC [U20] | 1:0 | ||||
| 3. Round | 22/01/2021 | Puebla FC [U20] | - | Club Tijuana [U20] | 0:2 | ||||
| 5. Round | 06/02/2021 | CF América [U20] | - | Puebla FC [U20] | 4:1 | ||||
| 6. Round | 12/02/2021 | Puebla FC [U20] | - | FC Juárez [U20] | 3:0 | ||||
| 7. Round | 21/02/2021 | Gallos Blancos [U20] | - | Puebla FC [U20] | 0:1 | ||||
| 8. Round | 26/02/2021 | Puebla FC [U20] | - | Club Necaxa [U20] | 3:2 | ||||
| 9. Round | 02/03/2021 | Club León [U20] | - | Puebla FC [U20] | 2:1 |  |
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| 10. Round | 05/03/2021 | Puebla FC [U20] | - | UANL Tigres [U20] | 3:2 | ||||
| 11. Round | 12/03/2021 | Puebla FC [U20] | - | Atlas Guadalajara [U20] | 0:5 | ||||
| 1. Round | 27/03/2021 | Puebla FC [U20] | - | Deportivo Guadalajara [U20] | 2:4 | ||||
| 13. Round | 02/04/2021 | Puebla FC [U20] | - | Mazatlán FC [U20] | 6:2 | ||||
| 4. Round | 07/04/2021 | Puebla FC [U20] | - | CF Monterrey [U20] | 2:3 | |
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| 14. Round | 12/04/2021 | CF Pachuca [U20] | - | Puebla FC [U20] | 5:2 | ||||
| 15. Round | 17/04/2021 | Atlético San Luis [U20] | - | Puebla FC [U20] | 5:3 | ||||
| 16. Round | 23/04/2021 | Puebla FC [U20] | - | Pumas UNAM [U20] | 3:2 | ||||
| 17. Round | 02/05/2021 | Santos Laguna [U20] | - | Puebla FC [U20] | 2:3 |
Mexico