| 1. Round | 20/07/2021 | Godoy Cruz | - | Rosario Central | 2:1 |  |
|||
| 2. Round | 25/07/2021 | Rosario Central | - | Vélez Sarsfield | 1:0 | ||||
| 3. Round | 29/07/2021 | Gimnasia de La Plata | - | Rosario Central | 1:0 | ||||
| 4. Round | 02/08/2021 | Rosario Central | - | Aldosivi | 1:2 | ||||
| 8. Round | 25/08/2021 | Rosario Central | - | Arsenal de Sarandí | 4:0 | ||||
| 9. Round | 29/08/2021 | Central Córdoba SdE | - | Rosario Central | 2:4 | ||||
| 25. Round | 11/12/2021 | Rosario Central | - | Huracán | 1:4 |
Argentina
Italy