| 2. Round | 03/09/2021 | Montpellier HSC [Women] | - | Paris Saint-Germain [Women] | 0:1 | ||||
| 3. Round | 10/09/2021 | EA Guingamp [Women] | - | Montpellier HSC [Women] | 2:1 |  |
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| 6. Round | 17/10/2021 | Olympique Lyonnais [Women] | - | Montpellier HSC [Women] | 5:0 | ||||
| 7. Round | 30/10/2021 | AS Saint-Étienne [Women] | - | Montpellier HSC [Women] | 1:2 |  |
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| 8. Round | 13/11/2021 | Montpellier HSC [Women] | - | GPSO 92 Issy [Women] | 3:0 | ||||
| 12. Round | 15/01/2022 | Montpellier HSC [Women] | - | AS Saint-Étienne [Women] | 3:0 | ||||
| 14. Round | 04/02/2022 | FC Fleury 91 [Women] | - | Montpellier HSC [Women] | 1:0 | ||||
| 17. Round | 19/03/2022 | Montpellier HSC [Women] | - | EA Guingamp [Women] | 6:0 | ||||
| 19. Round | 15/04/2022 | Paris FC [Women] | - | Montpellier HSC [Women] | 3:1 | ||||
| 20. Round | 07/05/2022 | Montpellier HSC [Women] | - | ASJ Soyaux [Women] | 3:0 | ||||
| 21. Round | 28/05/2022 | GPSO 92 Issy [Women] | - | Montpellier HSC [Women] | 2:5 | ||||
| 22. Round | 01/06/2022 | Montpellier HSC [Women] | - | Girondins Bordeaux [Women] | 0:1 |
France