| 1. Round | 05/02/2022 | Defensor Sporting | - | Liverpool | 0:3 |  |
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| 4. Round | 26/02/2022 | Liverpool | - | Danubio | 0:1 | ||||
| 5. Round | 04/03/2022 | Deportivo Maldonado | - | Liverpool | 1:0 | ||||
| 6. Round | 20/03/2022 | Liverpool | - | Rentistas | 1:0 |  |
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| 7. Round | 03/04/2022 | Cerrito | - | Liverpool | 0:1 | ||||
| 8. Round | 09/04/2022 | Peñarol | - | Liverpool | 2:1 | |
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| 9. Round | 16/04/2022 | Liverpool | - | Montevideo City Torque | 2:0 | ||||
| 10. Round | 23/04/2022 | Montevideo Wanderers | - | Liverpool | 0:0 | |
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| 11. Round | 07/05/2022 | Liverpool | - | Plaza Colonia | 1:0 | |
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| 12. Round | 16/05/2022 | Boston River | - | Liverpool | 2:3 | ||||
| 14. Round | 28/05/2022 | Cerro Largo | - | Liverpool | 1:2 | ||||
| 15. Round | 05/06/2022 | Liverpool | - | Fénix | 1:0 |
Uruguay