| 6. Round | 25/09/2021 | FC Bassecourt | - | Grasshopper Club Zürich II | 5:1 | ||||
| 7. Round | 03/10/2021 | Grasshopper Club Zürich II | - | FC Köniz | 3:3 | ||||
| 9. Round | 24/10/2021 | Grasshopper Club Zürich II | - | FC Solothurn | 2:2 |  |
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| 10. Round | 30/10/2021 | Grasshopper Club Zürich II | - | FC Kosova Zürich | 4:1 | |
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| 11. Round | 06/11/2021 | SV Höngg | - | Grasshopper Club Zürich II | 1:0 | ||||
| 15. Round | 05/03/2022 | Grasshopper Club Zürich II | - | Zug 94 | 2:0 | ||||
| 16. Round | 12/03/2022 | FC Schötz | - | Grasshopper Club Zürich II | 0:5 | ||||
| 17. Round | 19/03/2022 | Grasshopper Club Zürich II | - | FC Langenthal | 1:2 | |
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| 18. Round | 26/03/2022 | SC Buochs | - | Grasshopper Club Zürich II | 0:4 | ||||
| 19. Round | 03/04/2022 | Grasshopper Club Zürich II | - | FC Bassecourt | 5:2 | ||||
| 20. Round | 09/04/2022 | FC Köniz | - | Grasshopper Club Zürich II | 0:2 | ||||
| 21. Round | 23/04/2022 | Grasshopper Club Zürich II | - | FC Wohlen | 1:1 | |
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| 23. Round | 08/05/2022 | FC Kosova Zürich | - | Grasshopper Club Zürich II | 1:2 | ||||
| 24. Round | 14/05/2022 | Grasshopper Club Zürich II | - | SV Höngg | 1:0 | ||||
| 25. Round | 21/05/2022 | FC Luzern II | - | Grasshopper Club Zürich II | 4:0 |
Guinea-Bissau
Portugal