| 1. Round | 09/01/2021 | Pumas UNAM [Women] | - | Club Tijuana [Women] | 2:0 | ||||
| 2. Round | 19/01/2021 | Club Tijuana [Women] | - | Deportivo Toluca [Women] | 0:1 | ||||
| 3. Round | 26/01/2021 | Club Tijuana [Women] | - | Atlas Guadalajara [Women] | 0:1 | ||||
| 4. Round | 31/01/2021 | Atlético San Luis [Women] | - | Club Tijuana [Women] | 3:5 |  |
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| 5. Round | 04/02/2021 | Club Tijuana [Women] | - | Mazatlán FC [Women] | 0:0 | ||||
| 6. Round | 06/02/2021 | FC Juárez [Women] | - | Club Tijuana [Women] | 1:2 | ||||
| 7. Round | 16/02/2021 | Club Tijuana [Women] | - | Puebla FC [Women] | 0:0 | ||||
| 9. Round | 09/03/2021 | Club Tijuana [Women] | - | Deportivo Guadalajara [Women] | 2:1 | ||||
| 10. Round | 12/03/2021 | CF América [Women] | - | Club Tijuana [Women] | 1:2 |
Mexico