| 1. Round | 06/08/2022 | Vysočina Jihlava [Youth] | - | 1. FC Slovácko [Youth] | 1:1 | ||||
| 2. Round | 13/08/2022 | 1. FC Slovácko [Youth] | - | FK Pardubice [Youth] | 0:0 | ||||
| 3. Round | 19/08/2022 | Banik Ostrava [Youth] | - | 1. FC Slovácko [Youth] | 1:3 | ||||
| 4. Round | 27/08/2022 | 1. FC Slovácko [Youth] | - | Dynamo České Budějovice [Youth] | 1:3 | ||||
| 8. Round | 30/08/2022 | Viktoria Plzeň [Youth] | - | 1. FC Slovácko [Youth] | 0:2 | ||||
| 5. Round | 03/09/2022 | Sigma Olomouc [Youth] | - | 1. FC Slovácko [Youth] | 4:1 | ||||
| 6. Round | 10/09/2022 | AC Sparta Praha [Youth] | - | 1. FC Slovácko [Youth] | 4:1 | ||||
| 7. Round | 17/09/2022 | 1. FC Slovácko [Youth] | - | FK Mladá Boleslav [Youth] | 1:1 |  |
Czech Republic