| 1. Round | 16/07/2022 | Tacuary | - | Guaireña FC | 0:0 | ||||
| 2. Round | 21/07/2022 | Tacuary | - | Cerro Porteño | 0:1 | ||||
| 3. Round | 23/07/2022 | Sportivo Ameliano | - | Tacuary | 2:0 | ||||
| 4. Round | 31/07/2022 | Tacuary | - | Club Olimpia | 2:1 | ||||
| 5. Round | 06/08/2022 | General Caballero DJLM | - | Tacuary | 0:4 |  |
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| 6. Round | 15/08/2022 | Tacuary | - | Resistencia SC | 1:1 |  |
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| 10. Round | 11/09/2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 11. Round | 14/09/2022 | Libertad | - | Tacuary | 2:0 |  |
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| 12. Round | 18/09/2022 | Guaireña FC | - | Tacuary | 1:0 | ||||
| 13. Round | 25/09/2022 | Cerro Porteño | - | Tacuary | 5:0 | ||||
| 14. Round | 02/10/2022 | Tacuary | - | Sportivo Ameliano | 1:1 | |
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| 15. Round | 06/10/2022 | Club Olimpia | - | Tacuary | 1:0 | ||||
| 16. Round | 12/10/2022 | Tacuary | - | General Caballero DJLM | 0:3 | |
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| 17. Round | 15/10/2022 | Resistencia SC | - | Tacuary | 0:3 | |
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| 18. Round | 21/10/2022 | Tacuary | - | 12 de Octubre de Itauguá | 5:1 | ||||
| 19. Round | 25/10/2022 | Sol de América | - | Tacuary | 2:2 | |
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| 21. Round | 06/11/2022 | Guaraní | - | Tacuary | 2:1 | |
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| 22. Round | 12/11/2022 | Tacuary | - | Libertad | 1:0 |
Paraguay