| 1. Round | 18/07/2021 | Club Olimpia | - | River Plate | 1:3 |  |
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| 2. Round | 27/07/2021 | 12 de Octubre de Itauguá | - | Club Olimpia | 1:3 | ||||
| 3. Round | 02/08/2021 | Club Olimpia | - | Guaireña FC | 0:2 | ||||
| 4. Round | 07/08/2021 | Guaraní | - | Club Olimpia | 3:1 | ||||
| 7. Round | 28/08/2021 | Club Olimpia | - | Sol de América | 0:1 |  |
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| 16. Round | 21/11/2021 | Sol de América | - | Club Olimpia | 1:0 | ||||
| 17. Round | 26/11/2021 | Club Olimpia | - | Libertad | 2:3 | ||||
| 18. Round | 05/12/2021 | Club Nacional | - | Club Olimpia | 1:3 |
Paraguay