| 1. Round | 24/07/2021 | Deportivo Guadalajara [U20] | - | Atlético San Luis [U20] | 1:5 | ||||
| 2. Round | 30/07/2021 | Puebla FC [U20] | - | Deportivo Guadalajara [U20] | 3:1 |  |
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| 4. Round | 15/08/2021 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 1:2 | |
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| 5. Round | 18/08/2021 | Deportivo Guadalajara [U20] | - | Club León [U20] | 1:2 | ||||
| 6. Round | 21/08/2021 | CF Monterrey [U20] | - | Deportivo Guadalajara [U20] | 1:1 | |
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| 8. Round | 12/09/2021 | Pumas UNAM [U20] | - | Deportivo Guadalajara [U20] | 1:2 | ||||
| 9. Round | 18/09/2021 | Deportivo Guadalajara [U20] | - | CF Pachuca [U20] | 1:2 | ||||
| 10. Round | 25/09/2021 | CF América [U20] | - | Deportivo Guadalajara [U20] | 1:3 | ||||
| 11. Round | 29/09/2021 | Gallos Blancos [U20] | - | Deportivo Guadalajara [U20] | 1:2 | ||||
| 13. Round | 17/10/2021 | Deportivo Guadalajara [U20] | - | Deportivo Toluca [U20] | 4:1 | ||||
| 14. Round | 20/10/2021 | Club Tijuana [U20] | - | Deportivo Guadalajara [U20] | 1:2 | |
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| 15. Round | 23/10/2021 | Deportivo Guadalajara [U20] | - | Cruz Azul [U20] | 0:1 | |
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| 17. Round | 05/11/2021 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 1:0 | |
Mexico