| 3. Round | 03/04/2022 | Inter Miami CF | - | Houston Dynamo | 1:3 |  |
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| 3. Round | 09/04/2022 | Inter Miami CF | - | New England Revolution | 3:2 | ||||
| 3. Round | 17/04/2022 | Seattle Sounders | - | Inter Miami CF | 0:1 | ||||
| 3. Round | 24/04/2022 | Inter Miami CF | - | Atlanta United FC | 2:1 | |
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| 4. Round | 01/05/2022 | New England Revolution | - | Inter Miami CF | 2:0 | ||||
| 7. Round | 01/09/2022 | Columbus Crew | - | Inter Miami CF | 1:0 | ||||
| 8. Round | 11/09/2022 | Chicago Fire | - | Inter Miami CF | 3:1 |
Netherlands