| 1. Round | 09/01/2021 | Mazatlán FC | - | Club Necaxa | 3:2 | ||||
| 2. Round | 17/01/2021 | Pumas UNAM | - | Mazatlán FC | 3:0 | ||||
| 3. Round | 23/01/2021 | Mazatlán FC | - | Santos Laguna | 0:0 | ||||
| 4. Round | 30/01/2021 | Mazatlán FC | - | CF Pachuca | 1:0 |  |
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| 5. Round | 07/02/2021 | Deportivo Toluca | - | Mazatlán FC | 4:1 | |
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| 6. Round | 13/02/2021 | Mazatlán FC | - | Atlético San Luis | 0:3 | |
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| 7. Round | 20/02/2021 | FC Juárez | - | Mazatlán FC | 1:0 | ||||
| 8. Round | 27/02/2021 | Mazatlán FC | - | Gallos Blancos | 3:0 |  |
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| 10. Round | 07/03/2021 | Mazatlán FC | - | Deportivo Guadalajara | 1:1 | |
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| 11. Round | 14/03/2021 | UANL Tigres | - | Mazatlán FC | 1:2 | ||||
| 12. Round | 20/03/2021 | Mazatlán FC | - | CF América | 0:1 | ||||
| 13. Round | 03/04/2021 | Puebla FC | - | Mazatlán FC | 3:1 | |
Chile