| 4. Round | 28/08/2021 | SC Brühl | - | SC YF/Juventus Zürich | 2:5 | ||||
| 5. Round | 04/09/2021 | SC Cham | - | SC Brühl | 0:1 | ||||
| 6. Round | 11/09/2021 | SC Brühl | - | FC Black Stars Basel | 1:3 | ||||
| 7. Round | 18/09/2021 | FC Bavois | - | SC Brühl | 1:3 | ||||
| 8. Round | 25/09/2021 | SC Brühl | - | FC Stade Nyonnais | 2:5 | ||||
| 9. Round | 02/10/2021 | AC Bellinzona | - | SC Brühl | 2:1 | ||||
| 12. Round | 23/10/2021 | SC Brühl | - | FC Biel/Bienne | 1:1 | ||||
| 13. Round | 30/10/2021 | FC Basel 1893 II | - | SC Brühl | 1:3 | ||||
| 14. Round | 06/11/2021 | SC Brühl | - | FC Sion II | 0:1 | ||||
| 15. Round | 13/11/2021 | Etoile Carouge FC | - | SC Brühl | 2:1 |  |
|||
| 16. Round | 20/11/2021 | FC Zürich II | - | SC Brühl | 0:0 | ||||
| 17. Round | 27/11/2021 | SC Brühl | - | FC Breitenrain Bern | 1:3 | ||||
| 18. Round | 04/12/2021 | FC Rapperswil-Jona | - | SC Brühl | 2:1 |
Switzerland
Italy