| 2. Round | 25/09/2021 | Gavilanes de Matamoros | - | Coras de Nayarit | 0:0 | ||||
| 4. Round | 09/10/2021 | Gavilanes de Matamoros | - | Tuzos de la UAZ | 2:1 |  |
|||
| 6. Round | 16/10/2021 | Gavilanes de Matamoros | - | Cimarrones de Sonora II | 2:1 | ||||
| 7. Round | 23/10/2021 | Saltillo FC | - | Gavilanes de Matamoros | 3:1 | ||||
| 8. Round | 30/10/2021 | Gavilanes de Matamoros | - | Tritones Vallarta | 4:0 |
Mexico