| 1. Round | 03/09/2022 | Twente/Heracles [U21] | - | NAC Breda [U21] | 6:2 |  |
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| 2. Round | 10/09/2022 | FC Den Bosch [U21] | - | Twente/Heracles [U21] | 1:0 | ||||
| 3. Round | 16/09/2022 | Twente/Heracles [U21] | - | Vitesse [U21] | 2:0 | |
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| 4. Round | 01/10/2022 | Roda JC Kerkrade [U21] | - | Twente/Heracles [U21] | 0:3 | |
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| 5. Round | 08/10/2022 | Twente/Heracles [U21] | - | Go Ahead Eagles [U21] | 2:0 | |
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| 6. Round | 15/10/2022 | NEC Nijmegen [U21] | - | Twente/Heracles [U21] | 0:0 | ||||
| 7. Round | 22/10/2022 | Twente/Heracles [U21] | - | VVV-Venlo [U21] | 2:1 | |
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| 8. Round | 29/10/2022 | NAC Breda [U21] | - | Twente/Heracles [U21] | 0:1 | ||||
| 9. Round | 05/11/2022 | Twente/Heracles [U21] | - | FC Den Bosch [U21] | 1:0 | |
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| 10. Round | 11/11/2022 | Vitesse [U21] | - | Twente/Heracles [U21] | 2:4 | ||||
| 11. Round | 19/11/2022 | Twente/Heracles [U21] | - | Roda JC Kerkrade [U21] | 5:1 | |
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| 12. Round | 25/11/2022 | Go Ahead Eagles [U21] | - | Twente/Heracles [U21] | 0:3 | |
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| 13. Round | 06/12/2022 | Twente/Heracles [U21] | - | NEC Nijmegen [U21] | 2:0 | |
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| 14. Round | 17/12/2022 | VVV-Venlo [U21] | - | Twente/Heracles [U21] | 1:1 |
Netherlands