| 3. Round | 09/07/2022 | Mazatlán FC [U16] | - | Atlético San Luis [U16] | 3:2 | ||||
| 4. Round | 16/07/2022 | Atlético San Luis [U16] | - | Santos Laguna [U16] | 3:2 | ||||
| 9. Round | 20/08/2022 | Club Tijuana [U16] | - | Atlético San Luis [U16] | 3:2 | ||||
| 10. Round | 27/08/2022 | CF Monterrey [U16] | - | Atlético San Luis [U16] | 3:0 | ||||
| 11. Round | 03/09/2022 | Atlético San Luis [U16] | - | Club Tijuana [U16] | 1:0 | ||||
| 12. Round | 11/09/2022 | Deportivo Guadalajara [U16] | - | Atlético San Luis [U16] | 2:0 | ||||
| 14. Round | 24/09/2022 | UANL Tigres [U16] | - | Atlético San Luis [U16] | 0:0 | ||||
| 15. Round | 02/10/2022 | Atlético San Luis [U16] | - | Atlas Guadalajara [U16] | 0:2 | ||||
| 16. Round | 08/10/2022 | Santos Laguna [U16] | - | Atlético San Luis [U16] | 4:0 | ||||
| 17. Round | 15/10/2022 | Atlético San Luis [U16] | - | Mazatlán FC [U16] | 1:1 |
Mexico