| 1. Round | 25/07/2021 | Club Tijuana [U18] | - | UANL Tigres [U18] | 1:0 | ||||
| 2. Round | 01/08/2021 | Deportivo Toluca [U18] | - | UANL Tigres [U18] | 4:0 | ||||
| 3. Round | 07/08/2021 | UANL Tigres [U18] | - | Santos Laguna [U18] | 0:0 | ||||
| 4. Round | 13/08/2021 | Puebla FC [U18] | - | UANL Tigres [U18] | 1:2 | ||||
| 5. Round | 17/08/2021 | UANL Tigres [U18] | - | Gallos Blancos [U18] | 1:0 |  |
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| 7. Round | 28/08/2021 | UANL Tigres [U18] | - | Atlas Guadalajara [U18] | 0:0 | ||||
| 8. Round | 11/09/2021 | UANL Tigres [U18] | - | Club León [U18] | 1:1 | ||||
| 10. Round | 25/09/2021 | UANL Tigres [U18] | - | Pumas UNAM [U18] | 6:0 | ||||
| 14. Round | 20/10/2021 | UANL Tigres [U18] | - | CF Pachuca [U18] | 3:2 |
Mexico