| 1. Round | 18/09/2021 | UANL Tigres [] | - | Atlético San Luis [] | 5:0 | ||||
| 2. Round | 25/09/2021 | Deportivo Guadalajara [] | - | Atlético San Luis [] | 4:2 | ||||
| 3. Round | 02/10/2021 | Atlético San Luis [] | - | Santos Laguna [] | 1:1 | ||||
| 4. Round | 09/10/2021 | CF Monterrey [] | - | Atlético San Luis [] | 4:0 | ||||
| 5. Round | 16/10/2021 | Atlético San Luis [] | - | UANL Tigres [] | 2:2 |  |
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| 6. Round | 23/10/2021 | Club Necaxa [] | - | Atlético San Luis [] | 5:0 | ||||
| 7. Round | 30/10/2021 | Club León [] | - | Atlético San Luis [] | 2:0 | ||||
| 8. Round | 06/11/2021 | Atlético San Luis [] | - | Mazatlán FC [] | 2:2 |
Mexico