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| 05/11/2021 | 17:15 | UANL Tigres | - | Santos Laguna | 3:1 (1:0) | |
| 06/11/2021 | 15:00 | CF Pachuca | - | CF América | 5:3 (1:3) | |
| 15:30 | Club Necaxa | - | Club León | 3:3 (2:1) | ||
| 17:30 | Cruz Azul | - | Puebla FC | 2:2 (1:0) | ||
| 17:30 | Deportivo Toluca | - | Pumas UNAM | 3:1 (1:1) | ||
| 18:00 | Deportivo Guadalajara | - | Atlas Guadalajara | 3:0 (0:0) | ||
| 18:30 | FC Juárez | - | Club Tijuana | 1:1 (1:0) | ||
| 18:45 | Atlético San Luis | - | Mazatlán FC | 2:2 (0:1) |
| 1 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 7 | 5 | 1 | 1 | 30:11 | 19 | 16 |
| 2 |
|
CF América | 7 | 5 | 1 | 1 | 23:14 | 9 | 16 |
| 3 |
|
Club Tijuana | 7 | 3 | 1 | 3 | 14:14 | 0 | 10 |
| 4 |
|
Deportivo Toluca | 8 | 3 | 1 | 4 | 13:13 | 0 | 10 |
| 5 |
|
FC Juárez | 7 | 3 | 1 | 3 | 10:20 | -10 | 10 |
| 6 |
|
Pumas UNAM | 7 | 2 | 3 | 2 | 15:12 | 3 | 9 |
| 7 |
|
Puebla FC | 7 | 2 | 1 | 4 | 6:15 | -9 | 7 |
| 8 |
|
Cruz Azul | 8 | 1 | 3 | 4 | 15:23 | -8 | 6 |
| 9 |
|
Gallos Blancos | 6 | 1 | 2 | 3 | 5:9 | -4 | 5 |
| 2 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 7 | 6 | 0 | 1 | 20:7 | 13 | 18 |
| 2 |
|
UANL Tigres | 7 | 4 | 2 | 1 | 17:8 | 9 | 14 |
| 3 |
|
Club Necaxa | 7 | 4 | 1 | 2 | 17:9 | 8 | 13 |
| 4 |
|
Atlas Guadalajara | 7 | 4 | 0 | 3 | 11:11 | 0 | 12 |
| 5 |
|
Club León | 7 | 3 | 2 | 2 | 13:13 | 0 | 11 |
| 6 |
|
Santos Laguna | 7 | 3 | 1 | 3 | 10:11 | -1 | 10 |
| 7 |
|
CF Monterrey | 6 | 2 | 0 | 4 | 12:12 | 0 | 6 |
| 8 |
|
Mazatlán FC | 8 | 0 | 3 | 5 | 9:20 | -11 | 3 |
| 9 |
|
Atlético San Luis | 8 | 0 | 3 | 5 | 7:25 | -18 | 3 |
