| 1. Round | 16/08/2021 | West Ham United U23 | - | Arsenal FC U23 | 6:1 | ||||
| 2. Round | 20/08/2021 | Arsenal FC U23 | - | Crystal Palace U23 | 4:2 | ||||
| 3. Round | 27/08/2021 | Tottenham Hotspur U23 | - | Arsenal FC U23 | 1:2 | ||||
| 4. Round | 11/09/2021 | Arsenal FC U23 | - | Manchester United U23 | 3:1 | ||||
| 5. Round | 19/09/2021 | Chelsea FC U23 | - | Arsenal FC U23 | 1:6 |  |
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| 7. Round | 01/10/2021 | Arsenal FC U23 | - | Brighton & Hove Albion U23 | 3:0 | ||||
| 8. Round | 16/10/2021 | Liverpool FC U23 | - | Arsenal FC U23 | 3:0 |  |
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| 9. Round | 22/10/2021 | Arsenal FC U23 | - | Everton FC U23 | 4:0 | ||||
| 10. Round | 29/10/2021 | Leeds United U23 | - | Arsenal FC U23 | 2:4 | ||||
| 12. Round | 22/11/2021 | Blackburn Rovers U23 | - | Arsenal FC U23 | 2:3 | ||||
| 14. Round | 06/12/2021 | Everton FC U23 | - | Arsenal FC U23 | 2:0 | ||||
| 24. Round | 04/04/2022 | Arsenal FC U23 | - | Manchester City U23 | 3:3 | ||||
| 25. Round | 22/04/2022 | Manchester United U23 | - | Arsenal FC U23 | 1:1 | ||||
| 26. Round | 29/04/2022 | Arsenal FC U23 | - | Leeds United U23 | 1:1 |
Netherlands