| 1. Round | 08/01/2021 | Mazatlán FC [U20] | - | Club Necaxa [U20] | 2:0 | ||||
| 2. Round | 15/01/2021 | Club Necaxa [U20] | - | Atlético San Luis [U20] | 2:1 | ||||
| 3. Round | 24/01/2021 | Deportivo Toluca [U20] | - | Club Necaxa [U20] | 3:0 | ||||
| 5. Round | 05/02/2021 | Club Necaxa [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 7. Round | 19/02/2021 | Club Necaxa [U20] | - | CF Monterrey [U20] | 2:0 | ||||
| 8. Round | 26/02/2021 | Puebla FC [U20] | - | Club Necaxa [U20] | 3:2 |  |
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| 9. Round | 04/03/2021 | Club Necaxa [U20] | - | CF Pachuca [U20] | 1:1 | |
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| 10. Round | 07/03/2021 | Santos Laguna [U20] | - | Club Necaxa [U20] | 1:1 |  |
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| 11. Round | 15/03/2021 | Club León [U20] | - | Club Necaxa [U20] | 2:1 |  |
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| 13. Round | 03/04/2021 | CF América [U20] | - | Club Necaxa [U20] | 1:0 | ||||
| 14. Round | 09/04/2021 | Club Necaxa [U20] | - | Pumas UNAM [U20] | 1:0 | ||||
| 15. Round | 16/04/2021 | Club Necaxa [U20] | - | Gallos Blancos [U20] | 4:1 | |
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| 17. Round | 30/04/2021 | Club Necaxa [U20] | - | Atlas Guadalajara [U20] | 2:2 |
Mexico