| 1. Round | 05/07/2022 | CF Pachuca | - | Gallos Blancos | 2:0 | ||||
| 3. Round | 19/07/2022 | CF Pachuca | - | Mazatlán FC | 1:1 | ||||
| 4. Round | 25/07/2022 | CF Pachuca | - | Pumas UNAM | 0:0 | ||||
| 5. Round | 28/07/2022 | Club Necaxa | - | CF Pachuca | 2:0 | ||||
| 6. Round | 31/07/2022 | Deportivo Guadalajara | - | CF Pachuca | 0:0 | ||||
| 7. Round | 08/08/2022 | CF Pachuca | - | UANL Tigres | 2:0 | ||||
| 9. Round | 18/08/2022 | CF Pachuca | - | CF América | 0:3 | ||||
| 10. Round | 22/08/2022 | CF Pachuca | - | Club León | 1:0 | ||||
| 16. Round | 26/08/2022 | CF Pachuca | - | Atlas Guadalajara | 3:1 | ||||
| 11. Round | 28/08/2022 | Deportivo Toluca | - | CF Pachuca | 1:4 | ||||
| 12. Round | 03/09/2022 | CF Pachuca | - | Santos Laguna | 2:0 | ||||
| 13. Round | 08/09/2022 | Puebla FC | - | CF Pachuca | 2:2 | ||||
| 14. Round | 12/09/2022 | CF Pachuca | - | Club Tijuana | 6:1 | ||||
| 15. Round | 19/09/2022 | Atlético San Luis | - | CF Pachuca | 1:2 | ||||
| 17. Round | 01/10/2022 | CF Monterrey | - | CF Pachuca | 0:0 |
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