1. Round | 03/07/2022 | Atlético San Luis | - | Club León | 1:2 | ||||
3. Round | 16/07/2022 | Puebla FC | - | Club León | 1:1 | ||||
4. Round | 21/07/2022 | Deportivo Guadalajara | - | Club León | 0:0 | ||||
7. Round | 07/08/2022 | CF Monterrey | - | Club León | 5:1 | ||||
14. Round | 11/09/2022 | UANL Tigres | - | Club León | 0:1 | ||||
17. Round | 03/10/2022 | Club León | - | Club Tijuana | 2:2 |