| 1. Round | 15/07/2022 | Resistencia SC | - | Sol de América | 2:1 | ||||
| 2. Round | 21/07/2022 | Club Nacional | - | Resistencia SC | 1:1 | ||||
| 3. Round | 26/07/2022 | Resistencia SC | - | Guaraní | 0:0 | ||||
| 4. Round | 31/07/2022 | Libertad | - | Resistencia SC | 4:0 |  |
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| 5. Round | 05/08/2022 | Resistencia SC | - | Guaireña FC | 1:2 | ||||
| 6. Round | 15/08/2022 | Tacuary | - | Resistencia SC | 1:1 | ||||
| 8. Round | 27/08/2022 | Club Olimpia | - | Resistencia SC | 1:1 | ||||
| 9. Round | 03/09/2022 | Resistencia SC | - | General Caballero DJLM | 0:0 | ||||
| 10. Round | 10/09/2022 | Resistencia SC | - | Cerro Porteño | 0:2 | ||||
| 11. Round | 16/09/2022 | 12 de Octubre de Itauguá | - | Resistencia SC | 1:0 | ||||
| 14. Round | 03/10/2022 | Guaraní | - | Resistencia SC | 0:1 | ||||
| 15. Round | 06/10/2022 | Resistencia SC | - | Libertad | 1:0 | ||||
| 16. Round | 10/10/2022 | Guaireña FC | - | Resistencia SC | 3:2 | ||||
| 18. Round | 22/10/2022 | Sportivo Ameliano | - | Resistencia SC | 3:2 | |
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| 19. Round | 27/10/2022 | Resistencia SC | - | Club Olimpia | 1:6 |
Paraguay