| 1. Round | 07/08/2021 | RC Lens B | - | FC Fleury 91 | 1:3 | ||||
| 3. Round | 21/08/2021 | RC Lens B | - | FC Metz B | 0:2 | ||||
| 4. Round | 28/08/2021 | SC Schiltigheim | - | RC Lens B | 1:0 | ||||
| 5. Round | 04/09/2021 | RC Lens B | - | Entente SSG | 1:0 | ||||
| 6. Round | 11/09/2021 | SAS Épinal | - | RC Lens B | 4:0 | ||||
| 17. Round | 05/02/2022 | FC Metz B | - | RC Lens B | 0:0 |  |
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| 19. Round | 19/02/2022 | Entente SSG | - | RC Lens B | 1:0 | ||||
| 18. Round | 26/02/2022 | RC Lens B | - | SC Schiltigheim | 1:1 | ||||
| 20. Round | 05/03/2022 | RC Lens B | - | SAS Épinal | 0:1 | ||||
| 21. Round | 12/03/2022 | ASM Belfort | - | RC Lens B | 1:1 | |
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| 22. Round | 19/03/2022 | RC Lens B | - | Sainte-Geneviève-des-Bois | 0:0 | |
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| 23. Round | 26/03/2022 | Stade de Reims B | - | RC Lens B | 0:3 | ||||
| 25. Round | 16/04/2022 | FCSR Haguenau | - | RC Lens B | 0:1 | ||||
| 26. Round | 23/04/2022 | RC Lens B | - | Paris 13 Atletico | 1:1 | |
Senegal