| 1. Round | 24/07/2021 | CF Pachuca [U18] | - | Club León [U18] | 5:1 | ||||
| 4. Round | 14/08/2021 | Club León [U18] | - | Mazatlán FC [U18] | 1:1 | ||||
| 5. Round | 18/08/2021 | Deportivo Guadalajara [U18] | - | Club León [U18] | 1:1 | ||||
| 6. Round | 21/08/2021 | Club León [U18] | - | Santos Laguna [U18] | 3:1 | ||||
| 8. Round | 11/09/2021 | UANL Tigres [U18] | - | Club León [U18] | 1:1 | ||||
| 9. Round | 18/09/2021 | Club León [U18] | - | FC Juárez [U18] | 2:1 | ||||
| 10. Round | 25/09/2021 | Atlas Guadalajara [U18] | - | Club León [U18] | 2:3 | ||||
| 15. Round | 23/10/2021 | Puebla FC [U18] | - | Club León [U18] | 2:1 |
Mexico