| 1. Round | 16/07/2022 | Tacuary | - | Guaireña FC | 0:0 | ||||
| 2. Round | 19/07/2022 | Guaireña FC | - | Sportivo Ameliano | 3:1 | ||||
| 3. Round | 24/07/2022 | Club Olimpia | - | Guaireña FC | 2:1 | ||||
| 4. Round | 29/07/2022 | Guaireña FC | - | General Caballero DJLM | 1:2 | ||||
| 6. Round | 14/08/2022 | Guaireña FC | - | 12 de Octubre de Itauguá | 2:1 | ||||
| 7. Round | 20/08/2022 | Sol de América | - | Guaireña FC | 2:0 | ||||
| 18. Round | 21/10/2022 | Guaireña FC | - | Sol de América | 0:0 | ||||
| 19. Round | 27/10/2022 | Club Nacional | - | Guaireña FC | 3:0 | ||||
| 20. Round | 30/10/2022 | Guaireña FC | - | Guaraní | 1:0 | ||||
| 21. Round | 06/11/2022 | Libertad | - | Guaireña FC | 4:2 | ||||
| 22. Round | 12/11/2022 | Guaireña FC | - | Cerro Porteño | 1:3 |
Paraguay