| 15. Round | 06/10/2022 | Club Olimpia | - | Tacuary | 1:0 |  |
|||
| 16. Round | 12/10/2022 | Tacuary | - | General Caballero DJLM | 0:3 | ||||
| 17. Round | 15/10/2022 | Resistencia SC | - | Tacuary | 0:3 | ||||
| 18. Round | 21/10/2022 | Tacuary | - | 12 de Octubre de Itauguá | 5:1 | ||||
| 19. Round | 25/10/2022 | Sol de América | - | Tacuary | 2:2 | ||||
| 20. Round | 31/10/2022 | Tacuary | - | Club Nacional | 2:1 | ||||
| 21. Round | 06/11/2022 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Round | 12/11/2022 | Tacuary | - | Libertad | 1:0 |
Paraguay